Childhood Acute Lymphoblastic Leukemia : ’ Indian Experience
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چکیده
Of all cancers in childhood (by WHO definition: O-14 year age group), leukemias constitute one of the most important groups of tumors. Our understanding of the biologic features of the childhood leukemias has increased greatly over the past decade. The ability to discern cytogenetic and molecular differences among morphologically and immunologically similar populations of leukemic cells has helped to establish the basis for a revised classification of the leukemias. This advance, in turn, has led to new approaches to clinical management. Acute lymphoblastic leukemia (ALL) is diagnosed in approximately 2000 children in the United States each year, whereas acute myeloid leukemia (AML) is diagnosed in only about 500 children and chronic myeloidleukemia (CML) in fewer than 100.’ Chronic lymphocytic leukemia (CLL), one of the most common leukemias in adults seldom occurs in children. Leukemias and lymphomas followed closely by tumors of central nervous system constitute the vast majority of childhood cancers in India. In different population based cancer registries, leukemias constitute 27% to 52% of childhood cancers in males and 19% to 52% in female@. It was estimated that within a population of 882 million, six thousand children would develop acute lymphoblastic leukemia each year in India.3 With current population rates, this number is likely to increase.
منابع مشابه
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تاریخ انتشار 2005